pentobarbital will decrease the level or impact of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; steer clear of use in sufferers that are chronically employing a robust CYP3A4 inducerBarbiturates are weak acids that happen to be absorb